Differentiation Potential of Adipose-Derived Stem Cells When Cocultured with Smooth Muscle Cells, and the Role of Low-Intensity Laser Irradiation
These results suggest that ADSCs have the ability to differentiate into SMCs when cocultured with SMCs, whereas LILI potentially augments the differentiation potential and need. This further highlights the significant role that LILI has to offer ADSC therapy in regenerative medicine.
OPEN FILEEffects of Photobiomodulation and Mesenchymal Stem Cells on Articular Cartilage Defects in a Rabbit Model
In terms of our research, although better healing in osteochondral defects was seen when combining BMSCs and LLLT compared with the use of BMSCs alone, this improvement was predominantly caused by new bone formation rather than new cartilage formation.
OPEN FILEInduction of Autologous Mesenchymal Stem Cells in the Bone Marrow by Low-Level Laser Therapy Has Profound Beneficial Effects on the Infarcted Rat Heart
The application of LLLT to autologous BM of rats post-MI offers a novel approach to induce BM-derived MSCs, which are consequently recruited from the circulation to the infarcted heart and markedly attenuate the scarring process post-MI
OPEN FILELow-Level Laser Therapy to the Bone Marrow Reduces Scarring and Improves Heart Function Post-Acute Myocardial Infarction in the Pig
LLLT application to BM in the porcine model for MI caused a significant reduction in scarring, enhanced angiogenesis and functional improvement both in the acute and long term phase post-MI.
OPEN FILERegenerative Medicine, Stem Cells, and Low-Level Laser Therapy: Future Directives
However, it is the cellular effect of increasing proliferation and viability that may significantly contribute to the addition of LLLT to the many biomedical disciplines that further augment the successes of regenerative medicine. Low-intensity laser irradiation has been shown to induce stem cell activity by increasing migration, proliferation, and viability; activating protein expression, and inducing differentiation in progenitor cells.1
OPEN FILEEffect of Photobiomodulation on Mesenchymal Stem Cells
PBM has positive effects on MSCs. This review concluded that doses of 0.7–4 J/cm2 and wavelengths of 600–700 nm are appropriate for light therapy. The results were dependent upon different parameters; therefore, optimization of parameters used in light therapy to obtain favorable results is required to provide more accurate comparison.
OPEN FILESynergistic effects of low-level laser and mesenchymal stem cells on functional recovery in rats with crushed sciatic nerves
MSC transplantation combined with LLLT could achieve better results in functional recovery than a conventional treatment of MSC or LLLT alone. LLLT has a synergistic effect in providing greater functional recovery with MSC transplantation after nerve crush injury.
OPEN FILEPhotobiomodulation Therapy: Communicating with Stem Cells for Regeneration?
The major purpose of this special issue is to provide a collated overview of the progress and increasing excitement for the use of PBM therapy with stem cells for regenerative applications.
OPEN FILEEffect of Photobiomodulation Therapy on the Increase of Viability and Proliferation of Human Mesenchymal Stem Cells
Irradiation with the MLS M1 system can be used in vitro to modulate MSCs in preparation for therapeutic applications. This will assist in designing further studies to optimize the radiation parameters and elucidate the molecular mechanisms of action of the radiation.
OPEN FILEPhotobiomodulation Therapy Promotes Expansion of Epithelial Colony Forming Units
PBM therapy promotes expansion of eCFUs that represent progenitors and stem cell populations capable of contributing to tissue repair and regeneration. Further exploration of the precise mechanisms would allow optimization of PBM clinical protocols to harness the regenerative potential of stem cells for wound healing and other clinical regenerative applications.
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