Effects of Pulse Frequency of Low-Level Laser Therapy (LLLT) on Bone Nodule Formation in Rat Calvarial Cells

Since low-frequency pulsed laser irradiation significantly stimulates bone formation in vitro, it is most likely that the pulse frequency of LLLT an important factor affecting biological responses in bone formation.

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Effect of Laser Pulsing on Cell Viability

This study demonstrates the effect of laser pulsing on distinct cell types and suggests that optimization of laser treatments based on target cell types could improve clinical efficacy and therapeutic benefit for photobiomodulation

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Pulsing Influences Photoradiation Outcomes in Cell Culture

This investigation suggests that light pulsing may improve outcomes by mitigating the filtration effects of cutaneous melanin.

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The Necessity for Increased Attention to Pulsed Low-Level Laser Therapy

The PW LLLT device has more laser (illumination) parameters, such as peak and average power outputs, pulse frequency, and pulse duration, than CW LLLT, all of which add to the medical applicability of this technique.

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How Do We Know

Several studies showing different cell types responding to different frequencies of pulsed laser light.

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In Vivo Effects of Low Level Laser Therapy on Inducible Nitric Oxide Synthase

LLLT exhibit different effects in induced inflammatory process according to different wavelengths and wave mode.

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Effect of Pulsing in Low-Level Light Therapy

There is some evidence that pulsed light does have effects that are different from those of continuous wave light.

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Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes.

The results show that P mode NILT can result in significant clinical improvement when administered 6 h following embolic strokes in rabbits and should be considered for clinical development.

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Near infrared Transcranial Laser Therapy applied at Various Modes to Mice Following Traumatic Brain Injury Significantly Reduces Long-Term Neurological Deficits

Our data suggest that non-invasive TLT of mice post-TBI provides a significant long-term functional neurological benefit, and that the pulsed laser mode at 100 Hz is the preferred mode for such treatment.

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Effects of Pulsed 810nm Al/GaAs Diode Laser on Wound Healing Under Immunosuppression: A Molecular Insight

Taken together, these findings would be helpful in better understanding of the molecular aspects involved in pulsed 810 nm laser?mediated dermal wound healing in immunosuppressed rats through regulation of cell survival and proliferation via Ca2+?calmodulin, Akt, ERK, and redox signaling.

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